Discovery and SAR of Novel 2,3‐Dihydroimidazo[1,2‐c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80‐6946)

The phosphoinositide 3‐kinase (PI3K) pathway is aberrantly activated in many disease states, including tumor cells, either by growth factor receptor tyrosine kinases or by the genetic mutation and amplification of key pathway components. A variety of PI3K isoforms play differential roles in cancers....

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:ChemMedChem
المؤلفون الرئيسيون: Scott, William J., Hentemann, Martin F., Rowley, R. Bruce, Bull, Cathy O., Jenkins, Susan, Bullion, Ann M., Johnson, Jeffrey, Redman, Anikó, Robbins, Arthur H., Esler, William, Fracasso, R. Paul, Garrison, Timothy, Hamilton, Mark, Michels, Martin, Wood, Jill E., Wilkie, Dean P., Xiao, Hong, Levy, Joan, Stasik, Enrico, Liu, Ningshu, Schaefer, Martina, Brands, Michael, Lefranc, Julien
التنسيق: Artigo
اللغة:Inglês
منشور في: John Wiley and Sons Inc. 2016
الموضوعات:
Full Papers
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094563/
https://ncbi.nlm.nih.gov/pubmed/27310202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600148
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