BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone

Blood oxygen level dependent (BOLD) imaging in awake mice was used to identify differences in brain activity between wild-type, and Mu (μ) opioid receptor knock-outs (MuKO) in response to oxycodone (OXY). Using a segmented, annotated MRI mouse atlas and computational analysis, patterns of integrated...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Moore, Kelsey, Madularu, Dan, Iriah, Sade, Yee, Jason R., Kulkarni, Praveen, Darcq, Emmanuel, Kieffer, Brigitte L., Ferris, Craig F.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094148/
https://ncbi.nlm.nih.gov/pubmed/27857679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00471
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