PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear. Here we show that aerobic glycolysis...

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Publicado no:Nat Commun
Main Authors: Xie, Min, Yu, Yan, Kang, Rui, Zhu, Shan, Yang, Liangchun, Zeng, Ling, Sun, Xiaofang, Yang, Minghua, Billiar, Timothy R., Wang, Haichao, Cao, Lizhi, Jiang, Jianxin, Tang, Daolin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093342/
https://ncbi.nlm.nih.gov/pubmed/27779186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13280
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