Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

The inbred mouse strain C57BL/6J is widely used in models of immunological and infectious diseases. Here we show that C57BL/6J mice have a defect in neutrophil recruitment to a range of inflammatory stimuli compared with the related C57BL/6N substrain. This immune perturbation is associated with a m...

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Publicat a:Nat Commun
Autors principals: Ulland, Tyler K., Jain, Nidhi, Hornick, Emma E., Elliott, Eric I., Clay, Gwendolyn M., Sadler, Jeffrey J., Mills, Kathleen A. M., Janowski, Ann M., Volk, A. Paige Davis, Wang, Kai, Legge, Kevin L., Gakhar, Lokesh, Bourdi, Mohammed, Ferguson, Polly J., Wilson, Mary E., Cassel, Suzanne L., Sutterwala, Fayyaz S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093323/
https://ncbi.nlm.nih.gov/pubmed/27779193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13180
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