Combined (13)C-assisted metabolomics and metabolic flux analysis reveals the impacts of glutamate on the central metabolism of high β-galactosidase-producing Pichia pastoris

BACKGROUND: Pichia pastoris is a popular recombinant protein expression system for its accessibility of efficient gene manipulation and high protein production. Sufficient supply of precursors, energy, and redox cofactors is crucial for high recombinant protein production. In our present work, we fo...

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Vydáno v:Bioresour Bioprocess
Hlavní autoři: Liu, Ping, Huang, Mingzhi, Guo, Menglei, Qian, Jiangchao, Lin, Weilu, Chu, Ju, Zhuang, Yingping, Zhang, Siliang
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2016
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093185/
https://ncbi.nlm.nih.gov/pubmed/27867835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40643-016-0124-6
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