Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock

BACKGROUND: The therapeutic effect of aminoglycosides is highest and optimal when the peak plasma concentration (C (max))/minimal inhibitory concentration (MIC) ratio is between 8 and 10. The French guidelines recommend to use high doses of aminoglycosides for empiric antibiotic therapy in patients...

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Detalhes bibliográficos
Publicado no:Ann Intensive Care
Main Authors: Allou, Nicolas, Bouteau, Astrid, Allyn, Jérôme, Snauwaert, Aurélie, Valance, Dorothée, Jabot, Julien, Bouchet, Bruno, Galliot, Richard, Corradi, Laure, Montravers, Philippe, Augustin, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Paris 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093100/
https://ncbi.nlm.nih.gov/pubmed/27807818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13613-016-0211-z
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