Leukemic survival factor SALL4 contributes to defective DNA damage repair

SALL4 is aberrantly expressed in human myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We have generated a SALL4 transgenic (SALL4B Tg) mouse model with pre-leukemic MDS-like symptoms that transform to AML over time. This makes our mouse model applicable for studying human MDS/AML...

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Bibliographic Details
Published in:	Oncogene
Main Authors:	Wang, Fei, Gao, Chong, Lu, Jiayun, Tatetsu, Hiro, Williams, David A., Müller, Lars U, Cui, Wei, Chai, Li
Format:	Artigo
Language:	Inglês
Published:	2016
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5093088/ https://ncbi.nlm.nih.gov/pubmed/27132514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.146
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Leukemic survival factor SALL4 contributes to defective DNA damage repair

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