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BPTF Depletion Enhances T Cell Mediated Antitumor Immunity
Genetic studies in fruit flies have implicated the chromatin remodeling complex NURF in immunity, but it has yet to be studied in mammals. Here we show that its targeting in mice enhances antitumor immunity in two syngeneic models of cancer. NURF was disabled by silencing of BPTF, the largest and es...
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| Publié dans: | Cancer Res |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5093041/ https://ncbi.nlm.nih.gov/pubmed/27651309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3125 |
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