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Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

Membrane proteins (MPs) are essential components of cellular membranes and primary drug targets. Rational drug design relies on precise structural information, typically obtained by crystallography; however MPs are difficult to crystallize. Recent progress in MP structural determination has benefite...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Ishchenko, Andrii, Cherezov, Vadim, Liu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5092055/
https://ncbi.nlm.nih.gov/pubmed/27683972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/54463
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