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Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide.

Septic shock induced by lipopolysaccharide (LPS) triggering of cytokine production from monocytes/macrophages is a major cause of morbidity and mortality. The major monocyte/macrophage LPS receptor is the glycosylphosphatidylinositol (GPI)-anchored glycoprotein CD14. Here we demonstrate that CD14 co...

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Detalhes bibliográficos
Main Authors: Solomon, K R, Kurt-Jones, E A, Saladino, R A, Stack, A M, Dunn, I F, Ferretti, M, Golenbock, D, Fleisher, G R, Finberg, R W
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC509155/
https://ncbi.nlm.nih.gov/pubmed/9835628
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