Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis.

The immunodominant antimitochondrial antibody response in patients with primary biliary cirrhosis (PBC) is directed against the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Based on our earlier observations regarding peripheral blood mononuclear cell (PBMC) T cell epitopes, we reason...

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Pubblicato in:	J Clin Invest
Autori principali:	Shimoda, S, Van de Water, J, Ansari, A, Nakamura, M, Ishibashi, H, Coppel, R L, Lake, J, Keeffe, E B, Roche, T E, Gershwin, M E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1998
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509133/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9819369/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4213
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