Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.

Local production of immunosuppressive cytokines will be one of the most suitable therapeutic strategies against organ-specific autoimmune diabetes. To establish such a new therapy, we constructed recombinant adenoviral vectors with inserted mIL-12p40 (Ad.IL-12p40) and mIL-10 (Ad.IL-10). Sufficient a...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Yasuda, H, Nagata, M, Arisawa, K, Yoshida, R, Fujihira, K, Okamoto, N, Moriyama, H, Miki, M, Saito, I, Hamada, H, Yokono, K, Kasuga, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509130/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9819366/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2675
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