Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.

Local production of immunosuppressive cytokines will be one of the most suitable therapeutic strategies against organ-specific autoimmune diabetes. To establish such a new therapy, we constructed recombinant adenoviral vectors with inserted mIL-12p40 (Ad.IL-12p40) and mIL-10 (Ad.IL-10). Sufficient a...

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Main Authors: Yasuda, H, Nagata, M, Arisawa, K, Yoshida, R, Fujihira, K, Okamoto, N, Moriyama, H, Miki, M, Saito, I, Hamada, H, Yokono, K, Kasuga, M
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC509130/
https://ncbi.nlm.nih.gov/pubmed/9819366
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