Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions.

Since the natural immune response to hepatitis C virus (HCV) is often unable to clear the infection, to enhance immunogenicity we studied substituted peptides from an HCV cytotoxic T lymphocyte (CTL) epitope (C7A2) from a conserved region of the HCV core protein (DLMGYIPLV) recognized by CTL lines f...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Sarobe, P, Pendleton, C D, Akatsuka, T, Lau, D, Engelhard, V H, Feinstone, S M, Berzofsky, J A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509107/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9739058/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI3714
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