Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease.

The spotting lethal rat, a naturally occurring rodent model of Hirschsprung disease, carries a deletion in the endothelin-B receptor (EDNRB) gene that abrogates expression of functional EDNRB receptors. Rats homozygous for this mutation (sl) exhibit coat color spotting and congenital intestinal agan...

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Publicat a:J Clin Invest
Autors principals: Gariepy, C E, Williams, S C, Richardson, J A, Hammer, R E, Yanagisawa, M
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1998
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509092/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9739043/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI3702
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