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Identification of DNA primase inhibitors via a combined fragment-based and virtual screening
The structural differences between bacterial and human primases render the former an excellent target for drug design. Here we describe a technique for selecting small molecule inhibitors of the activity of T7 DNA primase, an ideal model for bacterial primases due to their common structural and func...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5090872/ https://ncbi.nlm.nih.gov/pubmed/27805033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36322 |
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