Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium.

Prostacyclin (PGI2) is a key mediator of pulmonary vasodilation in the perinatal period and its synthesis in the pulmonary vasculature increases markedly during late gestation due to enhanced expression of the rate-limiting enzyme cyclooxygenase-1 (COX-1). The hormone estrogen may play a role in COX...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Jun, S S, Chen, Z, Pace, M C, Shaul, P W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509079/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9649571/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2034
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