AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins.

AIDS patients who receive zidovudine (AZT) frequently suffer from myopathy. This has been attributed to mitochondrial (mt) damage, and specifically to the loss of mtDNA. This study examines whether AZT causes oxidative damage to DNA in patients and to skeletal muscle mitochondria in mice, and whethe...

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Bibliographic Details
Main Authors: de la Asunción, J G, del Olmo, M L, Sastre, J, Millán, A, Pellín, A, Pallardó, F V, Viña, J
Format: Artigo
Language:Inglês
Published: 1998
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC509058/
https://ncbi.nlm.nih.gov/pubmed/9649550
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