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An affinity-directed protein missile system for targeted proteolysis
The von Hippel–Lindau (VHL) protein serves to recruit the hypoxia-inducible factor alpha (HIF1α) protein under normoxia to the CUL2 E3 ubiquitin ligase for its ubiquitylation and degradation through the proteasome. In this report, we modify VHL to engineer an affinity-directed protein missile (AdPRO...
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| Publicado no: | Open Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5090066/ https://ncbi.nlm.nih.gov/pubmed/27784791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160255 |
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