Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.

The role of mutations of the granulocyte colony-stimulating factor receptor (G-CSFR) in the pathogenesis of severe congenital neutropenia (SCN) and the subsequent development of acute myeloid leukemia (AML) is controversial. Mice carrying a targeted mutation of their G-CSFR that reproduces the mutat...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	McLemore, M L, Poursine-Laurent, J, Link, D C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9691084/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI3216
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