Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.

Glucocorticoid-induced bone disease is characterized by decreased bone formation and in situ death of isolated segments of bone (osteonecrosis) suggesting that glucocorticoid excess, the third most common cause of osteoporosis, may affect the birth or death rate of bone cells, thus reducing their nu...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Weinstein, R S, Jilka, R L, Parfitt, A M, Manolagas, S C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9664068/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2799
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