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A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.

Mutations in multiple cardiac sarcomeric proteins including myosin heavy chain (MyHC) and cardiac troponin T (cTnT) cause a dominant genetic heart disease, familial hypertrophic cardiomyopathy (FHC). Patients with mutations in these two genes have quite distinct clinical characteristics. Those with...

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Published in:J Clin Invest
Main Authors: Tardiff, J C, Factor, S M, Tompkins, B D, Hewett, T E, Palmer, B M, Moore, R L, Schwartz, S, Robbins, J, Leinwand, L A
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1998
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508871/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9637714/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2389
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