A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma

BACKGROUND: Precision medicine approaches are ideally suited for rare tumors where comprehensive characterization may have diagnostic, prognostic, and therapeutic value. We describe the clinical case and molecular characterization of an adolescent with metastatic poorly differentiated carcinoma (PDC...

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Dades bibliogràfiques
Publicat a:Genome Med
Autors principals: Dela Cruz, Filemon S., Diolaiti, Daniel, Turk, Andrew T., Rainey, Allison R., Ambesi-Impiombato, Alberto, Andrews, Stuart J., Mansukhani, Mahesh M., Nagy, Peter L., Alvarez, Mariano J., Califano, Andrea, Forouhar, Farhad, Modzelewski, Beata, Mitchell, Chelsey M., Yamashiro, Darrell J., Marks, Lianna J., Bender, Julia L. Glade, Kung, Andrew L.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088685/
https://ncbi.nlm.nih.gov/pubmed/27799065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0366-0
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