Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration

In order to understand whether early epigenetic mechanisms instruct the long-term behavior of neural stem cells (NSCs) and their progeny, we examined Uhrf1 (ubiquitin-like PHD ring finger-1; also known as Np95), as it is highly expressed in NSCs of the developing brain and rapidly down-regulated upo...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Ramesh, Vidya, Bayam, Efil, Cernilogar, Filippo M., Bonapace, Ian M., Schulze, Markus, Riemenschneider, Markus J., Schotta, Gunnar, Götz, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088568/
https://ncbi.nlm.nih.gov/pubmed/27798843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.284992.116
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