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Osmotic Pressure Simulations of Amino Acids and Peptides Highlight Potential Routes to Protein Force Field Parameterization

Recent molecular dynamics (MD) simulations of proteins have suggested that common force fields overestimate the strength of amino acid interactions in aqueous solution. In an attempt to determine the causes of these effects, we have measured the osmotic coefficients of a number of amino acids using...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Miller, Mark S., Lay, Wesley K., Elcock, Adrian H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088389/
https://ncbi.nlm.nih.gov/pubmed/27052117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b01902
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