Leukocyte Adhesion Deficiency Type II is a generalized defect of de novo GDP-fucose biosynthesis. Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium.

Leukocyte Adhesion Deficiency Type II (LAD II) is a recently described syndrome and the two patients with this defect lack fucosylated glycoconjugates. These glycoconjugates include the selectin ligand, sialyl LewisX, and various fucosylated blood group antigens. To date, the molecular anomaly in th...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Karsan, A, Cornejo, C J, Winn, R K, Schwartz, B R, Way, W, Lannir, N, Gershoni-Baruch, R, Etzioni, A, Ochs, H D, Harlan, J M
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1998
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Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508833/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9616215/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI905
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