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Leukocyte Adhesion Deficiency Type II is a generalized defect of de novo GDP-fucose biosynthesis. Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium.

Leukocyte Adhesion Deficiency Type II (LAD II) is a recently described syndrome and the two patients with this defect lack fucosylated glycoconjugates. These glycoconjugates include the selectin ligand, sialyl LewisX, and various fucosylated blood group antigens. To date, the molecular anomaly in th...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: Karsan, A, Cornejo, C J, Winn, R K, Schwartz, B R, Way, W, Lannir, N, Gershoni-Baruch, R, Etzioni, A, Ochs, H D, Harlan, J M
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 1998
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508833/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9616215/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI905
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