Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea‐pigs

KEY POINTS: Channelopathies of autoimmune origin are novel and are associated with corrected QT (QTc) prolongation and complex ventricular arrhythmias. We have recently demonstrated that anti‐SSA/Ro antibodies from patients with autoimmune diseases and with QTc prolongation on the ECG target the hum...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Fabris, Frank, Yue, Yuankun, Qu, Yongxia, Chahine, Mohamed, Sobie, Eric, Lee, Peng, Wieczorek, Rosemary, Jiang, Xian‐Cheng, Capecchi, Pier‐Leopoldo, Laghi‐Pasini, Franco, Lazzerini, Pietro‐Enea, Boutjdir, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088251/
https://ncbi.nlm.nih.gov/pubmed/27296897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272151
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