Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation

Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life-threatening polymorphic ventricular tachycardia such as Torsades de Pointes. However, the functional and molecular mecha...

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Udgivet i:PLoS One
Main Authors: Aromolaran, Ademuyiwa S., Srivastava, Ujala, Alí, Alessandra, Chahine, Mohamed, Lazaro, Deana, El-Sherif, Nabil, Capecchi, Pier Leopoldo, Laghi-Pasini, Franco, Lazzerini, Pietro Enea, Boutjdir, Mohamed
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283635/
https://ncbi.nlm.nih.gov/pubmed/30521586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208321
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