Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium‐driven bile uptake

KEY POINTS: Acute biliary pancreatitis is a sudden and severe condition initiated by bile reflux into the pancreas. Bile acids are known to induce Ca(2+) signals and necrosis in isolated pancreatic acinar cells but the effects of bile acids on stellate cells are unexplored. Here we show that cholate...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Physiol
Hauptverfasser: Ferdek, Pawel E., Jakubowska, Monika A., Gerasimenko, Julia V., Gerasimenko, Oleg V., Petersen, Ole H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Molecular and cellular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088250/
https://ncbi.nlm.nih.gov/pubmed/27406326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272774
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge