Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium‐driven bile uptake

KEY POINTS: Acute biliary pancreatitis is a sudden and severe condition initiated by bile reflux into the pancreas. Bile acids are known to induce Ca(2+) signals and necrosis in isolated pancreatic acinar cells but the effects of bile acids on stellate cells are unexplored. Here we show that cholate...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Physiol
Main Authors: Ferdek, Pawel E., Jakubowska, Monika A., Gerasimenko, Julia V., Gerasimenko, Oleg V., Petersen, Ole H.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Molecular and cellular
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088250/
https://ncbi.nlm.nih.gov/pubmed/27406326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272774
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