A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.

Myasthenia gravis (MG) is caused by helper T cell-dependent autoantibodies against the muscle acetylcholine receptor (AChR). Thymic epithelial tumors (thymomas) occur in 10% of MG patients, but their autoimmunizing potential is unclear. They express mRNAs encoding AChR alpha and epsilon subunits, an...

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Detalhes bibliográficos
Main Authors: Nagvekar, N, Moody, A M, Moss, P, Roxanis, I, Curnow, J, Beeson, D, Pantic, N, Newsom-Davis, J, Vincent, A, Willcox, N
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508815/
https://ncbi.nlm.nih.gov/pubmed/9593783
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