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Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones.

Five single-point aquaporin-2 (AQP2) mutations that cause non-X-linked nephrogenic diabetes insipidus (NDI) were characterized to establish the cellular defect and to develop therapeutic strategies. In Xenopus oocytes expressing AQP2 cRNAs, single-channel water permeabilities of mutants L22V, T126M,...

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Bibliografiske detaljer
Main Authors: Tamarappoo, B K, Verkman, A S
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC508814/
https://ncbi.nlm.nih.gov/pubmed/9593782
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