Application of High-Throughput Next-Generation Sequencing for HLA Typing on Buccal Extracted DNA: Results from over 10,000 Donor Recruitment Samples

BACKGROUND: Unambiguous HLA typing is important in hematopoietic stem cell transplantation (HSCT), HLA disease association studies, and solid organ transplantation. However, current molecular typing methods only interrogate the antigen recognition site (ARS) of HLA genes, resulting in many cis-trans...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yin, Yuxin, Lan, James H., Nguyen, David, Valenzuela, Nicole, Takemura, Ping, Bolon, Yung-Tsi, Springer, Brianna, Saito, Katsuyuki, Zheng, Ying, Hague, Tim, Pasztor, Agnes, Horvath, Gyorgy, Rigo, Krisztina, Reed, Elaine F., Zhang, Qiuheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087893/
https://ncbi.nlm.nih.gov/pubmed/27798706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165810
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