A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.

The activity of the coagulation system is regulated, in part, by the interaction of thrombin with the endothelial cell receptor thrombomodulin with subsequent generation of activated protein C and suppression of thrombin production. Our previous investigation demonstrated that ablation of the thromb...

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Autores principales: Weiler-Guettler, H, Christie, P D, Beeler, D L, Healy, A M, Hancock, W W, Rayburn, H, Edelberg, J M, Rosenberg, R D
Formato: Artigo
Lenguaje:Inglês
Publicado: 1998
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC508785/
https://ncbi.nlm.nih.gov/pubmed/9576763
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