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A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.
The activity of the coagulation system is regulated, in part, by the interaction of thrombin with the endothelial cell receptor thrombomodulin with subsequent generation of activated protein C and suppression of thrombin production. Our previous investigation demonstrated that ablation of the thromb...
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| Gepubliceerd in: | J Clin Invest |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
1998
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508785/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576763/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2006 |
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