Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis

Somatic mutations in the Tp53 tumor suppressor gene are the most commonly seen genetic alterations in cancer, and germline mutations in Tp53 predispose individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulat...

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Udgivet i:Dis Model Mech
Main Authors: Hansen, Sarah A., Hart, Marcia L., Busi, Susheel, Parker, Taybor, Goerndt, Angela, Jones, Kevin, Amos-Landgraf, James M., Bryda, Elizabeth C.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087826/
https://ncbi.nlm.nih.gov/pubmed/27528400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.025767
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