Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking

Dopamine, a key striatal neuromodulator, increases synaptic strength by promoting surface insertion and/or retention of AMPA receptors (AMPARs). This process is mediated by the phosphorylation of the GluA1 subunit of AMPAR by cyclic nucleotide-dependent kinases, making cyclic nucleotide phosphodiest...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Song, Roy S., Tolentino, Rosa, Sobie, Eric A., Neves-Zaph, Susana R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087742/
https://ncbi.nlm.nih.gov/pubmed/27605670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749747
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