The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)(+) RNA Export

Genetic rearrangements are a hallmark of several forms of leukemia and can lead to oncogenic fusion proteins. One example of an affected chromosomal region is the gene coding for Nup214, a nucleoporin that localizes to the cytoplasmic side of the nuclear pore complex (NPC). We investigated two such...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Port, Sarah A., Mendes, Adélia, Valkova, Christina, Spillner, Christiane, Fahrenkrog, Birthe, Kaether, Christoph, Kehlenbach, Ralph H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087727/
https://ncbi.nlm.nih.gov/pubmed/27613868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.735340
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