Sevelamer Improves Steatohepatitis, Inhibits Liver and Intestinal Farnesoid X Receptor (FXR), and Reverses Innate Immune Dysregulation in a Mouse Model of Non-alcoholic Fatty Liver Disease

Bile acid sequestrants are synthetic polymers that bind bile acids in the gut and are used to treat dyslipidemia and hyperphosphatemia. Recently, these agents have been reported to lower blood glucose and increase insulin sensitivity by altering bile acid signaling pathways. In this study, we assess...

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Vydáno v:J Biol Chem
Hlavní autoři: McGettigan, Brett M., McMahan, Rachel H., Luo, Yuhuan, Wang, Xiaoxin X., Orlicky, David J., Porsche, Cara, Levi, Moshe, Rosen, Hugo R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087726/
https://ncbi.nlm.nih.gov/pubmed/27605663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731042
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