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Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site

Monitoring the environment with serine/threonine protein kinases is critical for growth and survival of Mycobacterium tuberculosis, a devastating human pathogen. Protein kinase B (PknB) is a transmembrane serine/threonine protein kinase that acts as an essential regulator of mycobacterial growth and...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Prigozhin, Daniil M., Papavinasasundaram, Kadamba G., Baer, Christina E., Murphy, Kenan C., Moskaleva, Alisa, Chen, Tony Y., Alber, Tom, Sassetti, Christopher M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087717/
https://ncbi.nlm.nih.gov/pubmed/27601474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731760
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