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Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors

Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in this context in vivo remain unclear. To understand Flt4 signaling better, we generated zebrafish bearing a deletion in the Flt4 cytoplasmic...

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Bibliografiska uppgifter
I publikationen:Development
Huvudupphovsmän: Shin, Masahiro, Male, Ira, Beane, Timothy J., Villefranc, Jacques A., Kok, Fatma O., Zhu, Lihua J., Lawson, Nathan D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Company of Biologists Ltd 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087638/
https://ncbi.nlm.nih.gov/pubmed/27621059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.137901
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