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Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors

Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in this context in vivo remain unclear. To understand Flt4 signaling better, we generated zebrafish bearing a deletion in the Flt4 cytoplasmic...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Shin, Masahiro, Male, Ira, Beane, Timothy J., Villefranc, Jacques A., Kok, Fatma O., Zhu, Lihua J., Lawson, Nathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087638/
https://ncbi.nlm.nih.gov/pubmed/27621059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.137901
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