Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism.

This study investigated the role of intracellular free Ca2+ concentration ([Ca2+]i) in apoptosis in MIN6 cells, an insulin secreting cell line, and in mouse islets. Thapsigargin, an inhibitor of sarcoendoplasmic reticulum Ca2+-ATPases (SERCA), caused a time- and concentration-dependent decrease in t...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Zhou, Y P, Teng, D, Dralyuk, F, Ostrega, D, Roe, M W, Philipson, L, Polonsky, K S
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508743/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9541492/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1245
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