Reduced Proteolytic Shedding of Receptor Tyrosine Kinases is a Post-Translational Mechanism of Kinase Inhibitor Resistance

Kinase inhibitor resistance often involves upregulation of poorly understood “bypass” signaling pathways. Here, we show that extracellular proteomic adaptation is one path to bypass signaling and drug resistance. Proteolytic shedding of surface receptors, which can provide negative feedback on signa...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Miller, Miles A., Oudin, Madeleine J., Sullivan, Ryan J., Wang, Stephanie J., Meyer, Aaron S., Im, Hyungsoon, Frederick, Dennie T., Tadros, Jenny, Griffith, Linda G., Lee, Hakho, Weissleder, Ralph, Flaherty, Keith T., Gertler, Frank B., Lauffenburger, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087317/
https://ncbi.nlm.nih.gov/pubmed/26984351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0933
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