CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment domain family member 9 (CARD9), a susceptibility gene for inflammatory bowel disease (IBD) that functi...

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Publicado en:Nat Med
Main Authors: Lamas, Bruno, Richard, Mathias L, Leducq, Valentin, Pham, Hang-Phuong, Michel, Marie-Laure, Da Costa, Gregory, Bridonneau, Chantal, Jegou, Sarah, Hoffmann, Thomas W, Natividad, Jane M, Brot, Loic, Taleb, Soraya, Couturier-Maillard, Aurélie, Nion-Larmurier, Isabelle, Merabtene, Fatiha, Seksik, Philippe, Bourrier, Anne, Cosnes, Jacques, Ryffel, Bernhard, Beaugerie, Laurent, Launay, Jean-Marie, Langella, Philippe, Xavier, Ramnik J, Sokol, Harry
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087285/
https://ncbi.nlm.nih.gov/pubmed/27158904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4102
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