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CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment domain family member 9 (CARD9), a susceptibility gene for inflammatory bowel disease (IBD) that functi...

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Библиографические подробности
Опубликовано в: :Nat Med
Главные авторы: Lamas, Bruno, Richard, Mathias L, Leducq, Valentin, Pham, Hang-Phuong, Michel, Marie-Laure, Da Costa, Gregory, Bridonneau, Chantal, Jegou, Sarah, Hoffmann, Thomas W, Natividad, Jane M, Brot, Loic, Taleb, Soraya, Couturier-Maillard, Aurélie, Nion-Larmurier, Isabelle, Merabtene, Fatiha, Seksik, Philippe, Bourrier, Anne, Cosnes, Jacques, Ryffel, Bernhard, Beaugerie, Laurent, Launay, Jean-Marie, Langella, Philippe, Xavier, Ramnik J, Sokol, Harry
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087285/
https://ncbi.nlm.nih.gov/pubmed/27158904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4102
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