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Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
Loss of function of the Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN antagonizes the Phosphatidylinositol 3′ kinase (PI3K) signaling pathway. PTEN also accumulates in the nucleus, where its functi...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087104/ https://ncbi.nlm.nih.gov/pubmed/23888040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1236188 |
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