miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity

Aberrant immune activation mediated by T effector cell populations is pivotal in the onset of autoimmunity in type 1 diabetes (T1D). T follicular helper (TFH) cells are essential in the induction of high-affinity antibodies, and their precursor memory compartment circulates in the blood. The role of...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Serr, Isabelle, Fürst, Rainer W., Ott, Verena B., Scherm, Martin G., Nikolaev, Alexei, Gökmen, Füsun, Kälin, Stefanie, Zillmer, Stephanie, Bunk, Melanie, Weigmann, Benno, Kunschke, Nicole, Loretz, Brigitta, Lehr, Claus-Michael, Kirchner, Benedikt, Haase, Bettina, Pfaffl, Michael, Waisman, Ari, Willis, Richard A., Ziegler, Anette-G., Daniel, Carolin
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087025/
https://ncbi.nlm.nih.gov/pubmed/27791035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606646113
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