Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity

Obesity is associated with low-grade inflammation that leads to insulin resistance and type 2 diabetes via Toll-like Receptor (TLR) and TNF-family cytokine receptor (TNFR) signaling pathways. Ubc13 is an ubiquitin-conjugating enzyme responsible for non-canonical K63-linked polyubiquitination of TNF...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Joo, Erina, Fukushima, Toru, Harada, Norio, Reed, John C., Matsuzawa, Shu-ichi, Inagaki, Nobuya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086849/
https://ncbi.nlm.nih.gov/pubmed/27796312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35983
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