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Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization

[Image: see text] Functionalized 4- and 6-azaindolines are accessible with high levels of enantioselectivity by the cation-directed cyclization of aminopyridine-derived imines via phase-transfer catalysis. The extension of this methodology to diastereoselective cyclizations is also described.

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Foilsithe in:Org Lett
Main Authors: Lamb, Alan D., Davey, Peter D., Driver, Russell W., Thompson, Amber L., Smith, Martin D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2016
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086784/
https://ncbi.nlm.nih.gov/pubmed/27709963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b02744
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