Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.

Aspirin causes bronchoconstriction in aspirin-intolerant asthma (AIA) patients by triggering cysteinyl-leukotriene (cys-LT) production, probably by removing PGE2-dependent inhibition. To investigate why aspirin does not cause bronchoconstriction in all individuals, we immunostained enzymes of the le...

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Autori principali: Cowburn, A S, Sladek, K, Soja, J, Adamek, L, Nizankowska, E, Szczeklik, A, Lam, B K, Penrose, J F, Austen, F K, Holgate, S T, Sampson, A P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC508632/
https://ncbi.nlm.nih.gov/pubmed/9466979
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